UFC on ESPN 65: Emmett vs. Murphy was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on April 5, 2025, at the UFC Apex in Enterprise, Nevada, part of the Las Vegas Valley, United States. A featherweight bout between former interim UFC Featherweight Championship challenger Josh Emmett and Lerone Murphy headlined the event.

Cast: Lerone Murphy, Josh Emmett, Pat Sabatini, Joanderson Brito, Chang Ho Lee, Cortavious Romious